MyBioSource.com's Mouse monoclonal c-IAP2 antibody is a Human, and Mouse monoclonal antibody. The Mouse monoclonal c-IAP2 antibody was generated using BIRC3, cIAP2, HIAP1, and IAP1 as the antigen. It reacts with Human, and Non-Human Primate. This antibody has been shown to work in applications such as: Western Blot.
Description
Multi-functional protein which regulates not only caspases and apoptosis,but also modulates inflammatory signaling and immunity,mitogenic kinase signaling and cell proliferation,as well as cell invasion and metastasis.Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions:acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1,RIPK2,RIPK3,RIPK4,CASP3,CASP7,CASP8,TRAF1,and BCL10.Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors(TLRs),Nodlike receptors (NLRs) and RIG-I like receptors (RLRs),collectively referred to as pattern recognition receptors (PRRs).Protects cells from spontaneous formation of the ripoptosome,a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases.The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione,a potent inducer of free radicals.It contains 3 baculovirus IAP repeats and a ring finger domain.Transcript variants encoding the same isoform have been identified.[provided by RefSeq,Aug 2011]